Target intelligence / Profile preview

P2X purinoceptor 3 (P2X3)

Target: P2X3
Molecular classification: Ligand-gated ion channel, P2X receptor, Purinergic receptor

Overview

P2X3 is a trimeric, ligand-gated non-selective cation channel activated by extracellular ATP. It is highly expressed in nociceptive sensory neurons, taste pathways and visceral afferents. P2X3 plays a crucial role in pain signaling, sensory hypersensitization, gustatory responses, and visceral reflexes. Selective antagonism of P2X3 shows promise for treating chronic pain, urinary tract disorders and refractory chronic cough.

Mechanism of action

Selective antagonism of P2X3 receptor

Biological functions

NociceptionSensory hypersensitizationGustatory responsesVisceral reflexesIon channel activityATP binding

Disease associations

Chronic painNeuropathic painUrinary bladder dysfunctionRefractory chronic cough

Interacting drugs

ATP

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