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Target intelligence / Profile preview
P2X Purinoceptor 4 (P2RX4)
- Target
- P2RX4
- Molecular classification
- Ligand-gated ion channel, P2X receptor
01
Overview
P2X purinoceptor 4 (P2RX4) is an ATP-gated cation channel belonging to the P2X receptor family. It plays roles in immunity, the central nervous system, inflammation, pain, and cardiovascular function. It is activated by extracellular ATP and allows cation influx (Na+/Ca2+). P2RX4 is expressed in various tissues including neurons, microglia, and endothelial cells. Its upregulation is implicated in neuropathic pain and inflammation, making it a potential therapeutic target.
- Other names
- ATP receptorPurinergic receptorP2X₄Purinergic receptor type 4
02
Mechanism of action
ATP-gated cation channel activation
03
Biological functions
Immunity modulationCentral nervous system signalingInflammationPain perceptionCardiovascular regulationCation channel activity
04
Disease associations
Neuropathic painInflammationEpilepsyPulmonary inflammation
05
Safety considerations
Potential for off-target effects due to widespread expressionComplexity of purinergic signaling pathways
06
Interacting drugs
ATP
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