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Target intelligence / Profile preview
P2X Purinoceptor 7 Receptor (P2X7)
- Target
- P2X7
- Molecular classification
- Receptor, Ion channel, Ligand-gated ion channel
01
Overview
The P2X7 purinoceptor is a ligand-gated ion channel activated by extracellular ATP. It forms a homo-trimeric complex and is characterized by a long C-terminal tail. Activation leads to cation influx, K+ efflux, and pore formation. It plays a crucial role in inflammation by activating the NLRP3 inflammasome and releasing pro-inflammatory cytokines. It's implicated in various diseases, including cardiovascular and neurodegenerative disorders.
- Other names
- P2Z receptorPurinergic receptor P2X, ligand-gated ion channel, 7
02
Mechanism of action
Ligand-gated ion channel activation
03
Biological functions
Cell depolarizationImmune responseInflammationCell deathPattern recognition
04
Disease associations
Chronic inflammatory diseasesCardiovascular diseaseNeurodegenerative diseaseAutoimmune conditions
05
Safety considerations
Exacerbation of inflammatory responsesPotential for ATP-dependent lysis
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