P2Y purinergic receptor family (P2Y receptor)

The P2Y purinergic receptor family consists of multiple subtypes of G protein-coupled receptors that bind extracellular nucleotides, triggering intracellular signaling cascades and modulating diverse physiological processes, including platelet aggregation, inflammation, cell proliferation, and muscle contraction. These receptors play key roles in cardiovascular health, immune responses, and some neurological and inflammatory diseases. Several subtypes serve as major drug targets for conditions like thrombosis and dry eye; however, drug development is challenged by limited ligand selectivity and risks related to bleeding or immune modulation.

Other names

P2Y receptor familyP2Y GPCRspurinergic P2Y receptorsmetabotropic P2 receptors

Agonism (activation of GPCR signaling, e.g., diquafosol at P2Y2); Antagonism (blocking platelet aggregation by inhibiting ADP binding at P2Y12, e.g., ticagrelor)