Purinergic receptor P2Y11 (P2Y11)

Purinergic receptor P2Y11 is a member of the G protein-coupled receptor (GPCR) family, distinguished by its ability to respond to extracellular ATP (and possibly NAD+) and to couple to both phospholipase C (via Gq) and adenylyl cyclase (via Gs) signaling pathways—a unique feature among P2Y receptors[1][6][7][9]. P2Y11 plays critical roles in modulating immune responses, including regulation of cytokine production, cell migration (notably in T lymphocytes), and inflammation[3][4][5][7][9][10]. The receptor is expressed in a variety of immune cells such as dendritic cells, macrophages, and T cells, and redistribution of P2Y11 within migrating cells helps orchestrate polarization and efficient movement, particularly during immune responses[3][5]. Lack of rodent orthologs, limited antagonists, and complex signaling hamper its study, but P2Y11 is increasingly recognized as a modulator of inflammation, immune cell migration, and certain disease processes related to immune function and infection[1][4][9][10].

Other names

purinergic receptor P2Y, G-protein coupled, 11P2RY11P2Y purinoceptor 11

Agonists (e.g., ATP, possibly NAD+) activate P2Y11 to stimulate both phospholipase C (PLC) and adenylyl cyclase (AC) pathways, leading to increased intracellular calcium and cAMP; Antagonists (e.g., NF157) block these signaling pathways[1][6][9]