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Target intelligence / Profile preview
P2Y Purinoceptor 2 (P2Y2)
- Target
- P2Y2
- Molecular classification
- G protein-coupled receptor, GPCR, Class A GPCR, Purinergic receptor, P2Y receptor
01
Overview
P2Y purinoceptor 2 (P2Y2) is a G protein-coupled receptor activated by ATP and UTP. It plays a role in various physiological processes including chloride secretion, adipocyte differentiation, immune modulation, and cell cycle control. It is implicated in diseases like cystic fibrosis, obesity, and cancer, making it a potential therapeutic target. However, current antagonists face challenges related to selectivity and bioavailability.
- Other names
- P2RY2HP2UP2RU1P2UP2U1P2URP2Y₂RPurinergic receptor P₂Y₂
02
Mechanism of action
Agonist or antagonist binding to the P2Y2 receptor, modulating downstream signaling pathways such as Ca²⁺/IP₃ and AKT/GSK3β/VEGF.
03
Biological functions
Chloride secretionAdipocyte differentiationImmune cell chemotaxisCell cycle controlSignal transduction
04
Disease associations
Cystic fibrosisObesityInsulin resistanceCancerInflammation
05
Safety considerations
Selectivity of antagonistsOral bioavailability of antagonistsMetabolic stability of antagonists
06
Interacting drugs
ATP
4 more in the full profile.
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