Purinoceptor P2Y6 (P2Y6)

Purinoceptor P2Y6 is a G protein-coupled receptor encoded by the *P2RY6* gene in humans. It is primarily activated by extracellular uridine diphosphate (UDP), with partial responsiveness to uridine triphosphate (UTP) and adenosine diphosphate (ADP), but not ATP. The receptor mediates its effects through G proteins that activate a phosphatidylinositol-calcium second messenger system. Purinoceptor P2Y6 is expressed in various tissues, notably immune cells such as microglia, where it plays roles in phagocytosis and modulation of inflammatory responses. It has been implicated in several pathological conditions including neurodegenerative diseases like Alzheimer’s and Parkinson’s diseases, ischemic stroke, radiation-induced brain injury, neuropathic pain, allergic airway inflammation, and cardiovascular events such as myocardial infarction. Pharmacologically relevant antagonists include MRS2578. The functional diversity of this receptor makes it an emerging therapeutic target for central nervous system disorders involving neuroinflammation.

Other names

Pyrimidinergic receptor P2Y6P2Y purinoceptor 6P2RY6PP2891

Agonists or antagonists modulate the receptor’s activity by binding to the extracellular domain, influencing downstream G protein-mediated signaling pathways such as phosphatidylinositol-calcium second messenger system activation. Antagonists like MRS2578 inhibit UDP-induced responses including immune cell activation and inflammatory mediator release.