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Target intelligence / Profile preview
P2Y12 purinergic receptor
- Molecular classification
- G protein-coupled receptor (GPCR), Purinergic receptor, GPCR1 family
01
Overview
The P2Y12 purinergic receptor is a G protein-coupled receptor primarily activated by adenosine diphosphate (ADP). It plays a crucial role in platelet aggregation and microglial function. In platelets, it is essential for ADP-induced platelet activation and thrombus formation, making it a key target for antiplatelet drugs. Within the central nervous system, it is exclusively expressed on microglia, where it participates in physiological monitoring of neuronal function and microglial neuroprotection. Genetic polymorphisms in the P2RY12 gene have been associated with altered risk for various diseases, including epilepsy, acute myocardial infarction, and bleeding disorders.
- Other names
- Purinoceptor 12ADP-glucose receptorG-protein coupled receptor SP1999Gi-coupled ADP receptor HORK3
02
Mechanism of action
Irreversible or reversible antagonism of ADP-mediated platelet aggregation by blocking the P2Y12 receptor.
03
Biological functions
Platelet aggregationMicroglial surveillanceHemostasisSignal transduction
04
Disease associations
Thromboembolic eventsMyocardial infarctionStrokeEpilepsyAcute myocardial infarctionBleeding disordersInflammatory conditionsCardiovascular diseaseNeurodegenerative disease
05
Safety considerations
Bleeding risk
06
Interacting drugs
Clopidogrel
1 more in the full profile.
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