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Target intelligence / Profile preview
P2Y12 purinoceptor 12 (P2RY12)
- Target
- P2RY12
- Molecular classification
- G protein-coupled receptor, GPCR, Purinergic receptor, Receptor
01
Overview
P2Y12 purinoceptor 12 (P2RY12) is a G protein-coupled receptor that primarily functions as a chemoreceptor for adenosine diphosphate (ADP). Highly expressed on platelets and microglia, it mediates ADP-induced platelet aggregation and regulates microglial actions. It is a major therapeutic target for antithrombotic drugs.
- Other names
- SP1999P2Y12 platelet ADP receptorNucleotide P2Y(12) receptorAdenosine P2Y12 receptorADPG-R
02
Mechanism of action
Blocks receptor function on platelets, reducing clot formation risk.
03
Biological functions
Platelet aggregationPlatelet activationSignal transductionThrombus growthNeuroprotectionMicroglial function
04
Disease associations
Thromboembolic disordersMyocardial infarctionStrokeEpilepsyAcute myocardial infarctionThrombosisSepsis
05
Safety considerations
Bleeding risk
06
Interacting drugs
Clopidogrel
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