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Target intelligence / Profile preview
p38α Mitogen-Activated Protein Kinase (p38α)
- Target
- p38α
- Molecular classification
- Enzyme, Serine/threonine protein kinase, MAPK
01
Overview
p38α, also known as MAPK14, is a serine/threonine protein kinase and a member of the mitogen-activated protein kinase (MAPK) family. It plays a central role in cellular responses to stress and inflammation, integrating multiple external cues to regulate diverse cellular functions. p38α is ubiquitously expressed in human tissues and is the most widely studied isoform among the four p38 MAPKs: p38α (MAPK14), p38β (MAPK11), p38γ (MAPK12), and p38δ (MAPK13).
- Other names
- MAPK14CSBP (\"cytokine suppressive drug binding protein\")RK (\"reactivating kinase\")
02
Mechanism of action
Inhibition of ATP binding to p38α kinase domain
03
Biological functions
Stress responseInflammation responseApoptosisCell cycle regulationGene expression regulationSynaptic plasticity
04
Disease associations
Rheumatoid arthritisNeurodegenerationCNS autoimmunityCardiovascular diseaseCancerMuscle wastingMyopathiesInflammation
05
Safety considerations
Complex roles depending on contextPotential for incomplete pathway shutdownContext dependent effects on apoptosis (pro-apoptotic vs anti-apoptotic)
06
Interacting drugs
SB203580
1 more in the full profile.
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