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Target intelligence / Profile preview
p38β Mitogen-Activated Protein Kinase (p38β)
- Target
- p38β
- Molecular classification
- Enzyme, Protein Kinase, Serine/Threonine Kinase, MAPK, Mitogen-Activated Protein Kinase
01
Overview
p38β, also known as MAPK11, is a serine/threonine protein kinase that plays a role in cellular responses to stress and inflammatory stimuli. It's part of the p38 MAPK family and is activated by extracellular signals. Unlike other MAPKs, p38β can spontaneously autoactivate. It participates in cell proliferation, differentiation, glucose/lipid metabolism, secretion, stress response, apoptosis, autophagy, and cell migration. It's highly expressed in endothelial cells but has low expression in leukocytes. Small molecule inhibitors like SB202190 and SB203580 inhibit p38β.
- Other names
- MAPK11
02
Mechanism of action
Small molecule inhibitors that inhibit kinase activity
03
Biological functions
Signal transductionCell proliferationCell differentiationGlucose metabolismLipid metabolismSecretionStress responseApoptosisAutophagyCell migrationRegulation of inflammatory signaling pathways
04
Disease associations
CancerInflammationMultiple MyelomaBone Destruction
05
Interacting drugs
SB202190
1 more in the full profile.
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