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Target intelligence / Profile preview
p38 Alpha Mitogen-Activated Protein Kinase (p38 alpha)
- Target
- p38 alpha
- Molecular classification
- Enzyme, Serine/threonine kinase, MAP kinase
01
Overview
p38 alpha, also known as MAPK14, is a serine/threonine kinase that plays crucial roles in cellular responses to stress stimuli, inflammation, and various physiological processes. It is activated by upstream kinases MKK3 and MKK6 and phosphorylates numerous downstream targets including kinases, transcription factors, and other proteins, influencing cell cycle regulation, apoptosis, synaptic plasticity, inflammation, and muscle function. It is being investigated as a therapeutic target for arthritic and inflammatory diseases, ischemic heart failure, and cardiac regeneration.
- Other names
- MAPK14CSPB1CSBP1CSBP2
02
Mechanism of action
Inhibition of p38 alpha kinase activity
03
Biological functions
Signal transductionCell cycle regulationApoptosisInflammationSynaptic plasticityMuscle functionStress response
04
Disease associations
Arthritic diseasesInflammatory diseasesIschemic heart failureCardiac hypertrophyCardiomyopathyCNS autoimmunity
05
Safety considerations
Precise role in cardiac hypertrophy is controversialPersistent activation in muscle satellite cells due to aging impairs muscle regeneration
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