Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
p38 MAPK-CREB signaling pathway (p38-CREB pathway)
- Target
- p38-CREB pathway
- Molecular classification
- Kinase (p38 MAPK), Transcription Factor (CREB)
01
Overview
The p38 MAPK-CREB pathway is a critical signaling cascade involved in cellular responses to stress, inflammation, and differentiation. p38 MAPK activates CREB by phosphorylation, which regulates transcription of genes important for cell survival, differentiation, and proliferation. This pathway plays significant roles in various diseases, including cancer and neurodegenerative disorders. While it is not a single target molecule, modulating this pathway can be therapeutic for several conditions.
- Other names
- p38 MAPK-CREB signaling pathwayp38-ATF/CREB pathway
02
Mechanism of action
Inhibition of p38 MAPK to reduce inflammation or cancer progression. Activation of CREB to enhance cell survival or differentiation.
03
Biological functions
Signal TransductionCell ProliferationApoptosisImmune ResponseStress ResponseCell Differentiation
04
Disease associations
CancerInflammationNeurodegenerative DiseaseCardiovascular Disease
05
Safety considerations
Potential for off-target effects due to the broad roles of p38 MAPK and CREB in cellular processes
06
Interacting drugs
SB203580 (inhibitor of p38 MAPK)
2 more in the full profile.
07
Biomarkers
Phosphorylated CREB (S133) and p38 MAPK activity levels
Beyond the preview
Go deeper on p38 MAPK-CREB signaling pathway (p38-CREB pathway).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on p38 MAPK-CREB signaling pathway (p38-CREB pathway).