Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
p38 mitogen–activated protein kinase (p38 MAPK)
- Target
- p38 MAPK
- Molecular classification
- Enzyme, Serine/threonine kinase, MAP kinase
01
Overview
p38 mitogen-activated protein kinases are a family of serine/threonine kinases that play a central role in cellular responses to stress and inflammation. They are part of the larger MAP kinase family, which transduces extracellular signals into various intracellular responses. Dysregulation or persistent activation of this pathway has been implicated in numerous diseases, including inflammatory disorders, cancer progression/metastasis, neurodegenerative diseases, cardiovascular disease and muscular dystrophies. Numerous small-molecule inhibitors targeting various isoforms have been developed for potential therapeutic use.
- Other names
- MAPK14CSPB1CSBP1CSBP2p38αMAPK11p38βMAPK12ERK6p38γMAPK13SAPK4p38δ
02
Mechanism of action
Inhibition of kinase activity by binding to the ATP binding site or other allosteric sites.
03
Biological functions
Signal transductionStress responseInflammation regulationCell differentiationApoptosisAutophagyCell cycle controlRegulation of gene expression
04
Disease associations
Inflammatory disordersCancerNeurodegenerative diseasesCardiovascular diseaseMuscular dystrophies
05
Safety considerations
Specificity issuesToxicity profilesCompensatory pathway activation
06
Interacting drugs
Small-molecule inhibitors (various isoforms)
Beyond the preview
Go deeper on p38 mitogen–activated protein kinase (p38 MAPK).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on p38 mitogen–activated protein kinase (p38 MAPK).