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Target intelligence / Profile preview
p38 mitogen-activated protein kinase alpha (p38α)
- Target
- p38α
- Molecular classification
- Enzyme, Protein Kinase, Serine/Threonine Kinase, MAPK
01
Overview
p38α, also known as MAPK14, is a serine/threonine protein kinase and a member of the mitogen-activated protein kinase (MAPK) family. It plays central roles in cellular responses to stress, inflammatory signaling, cell survival/apoptosis, proliferation/differentiation/migration, and mRNA stability. It is activated by dual phosphorylation at the TGY motif by upstream kinases. p38α has complex roles in disease, acting as a tumor suppressor during early tumorigenesis but potentially promoting tumor progression at later stages or under certain conditions. Current inhibitors often lack selectivity, posing a challenge for therapeutic development.
- Other names
- MAPK14
02
Mechanism of action
Inhibition of p38α kinase activity
03
Biological functions
Signal transductionCellular responses to stressInflammatory signalingCell survivalApoptosisProliferationDifferentiationMigrationmRNA stability
04
Disease associations
Inflammatory DiseasesCancerTumor suppressorTumor promotionPancreatic adenocarcinoma
05
Safety considerations
Lack of selectivity in current inhibitorsComplex and context-dependent roles in cancer
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