Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
p38 mitogen-activated protein kinase alpha (p38α)
- Target
- p38α
- Molecular classification
- Enzyme, Protein Kinase, Serine/Threonine Kinase, MAPK
01
Overview
p38α, also known as MAPK14, is a serine/threonine protein kinase and a member of the mitogen-activated protein kinase (MAPK) family. It plays central roles in cellular responses to stress, inflammatory signaling, cell survival/apoptosis, proliferation/differentiation/migration, and mRNA stability. It is activated by dual phosphorylation at the TGY motif by upstream kinases. p38α has complex roles in disease, acting as a tumor suppressor during early tumorigenesis but potentially promoting tumor progression at later stages or under certain conditions. Current inhibitors often lack selectivity, posing a challenge for therapeutic development.
- Other names
- MAPK14
02
Mechanism of action
Inhibition of p38α kinase activity
03
Biological functions
Signal transductionCellular responses to stressInflammatory signalingCell survivalApoptosisProliferationDifferentiationMigrationmRNA stability
04
Disease associations
Inflammatory DiseasesCancerTumor suppressorTumor promotionPancreatic adenocarcinoma
05
Safety considerations
Lack of selectivity in current inhibitorsComplex and context-dependent roles in cancer
Beyond the preview
Go deeper on p38 mitogen-activated protein kinase alpha (p38α).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on p38 mitogen-activated protein kinase alpha (p38α).