P3H2 antisense RNA 1 (P3H2-AS1)

P3H2 antisense RNA 1 (P3H2-AS1), also known as LEPREL1-AS1, is a long non-coding antisense RNA gene located on chromosome 3 that is transcribed from the strand opposite to the protein-coding LEPREL1 gene[3][5][9]. As an antisense RNA, it is classified as a long non-coding RNA (lncRNA) and is thought to potentially regulate the expression of the LEPREL1 gene by mechanisms such as transcriptional interference or RNA-induced translation inhibition[2][10]. LEPREL1 encodes prolyl 3-hydroxylase 2, an enzyme essential for collagen modification and normal eye development, and loss-of-function mutations in LEPREL1 can cause severe ocular disorders[1][8]; however, there is currently no direct evidence that P3H2-AS1 itself is a therapeutic target, disease gene, or biomarker[2][3][7][9]. No drugs targeting P3H2-AS1 or disease links specific to this RNA have been reported, and its biological function remains largely uncharacterized.

Other names

LEPREL1-AS1LEPREL1 antisense RNA 1 (non-protein coding)