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Target intelligence / Profile preview
P450 11β-hydroxylase (CYP11B1)
- Target
- CYP11B1
- Molecular classification
- Enzyme, Cytochrome P450, Monooxygenase
01
Overview
P450 11β-hydroxylase (CYP11B1) is a mitochondrial enzyme responsible for the final step in cortisol synthesis, converting 11-deoxycortisol to cortisol. It plays a crucial role in glucocorticoid production and is a therapeutic target for conditions involving cortisol excess or deficiency. Mutations in CYP11B1 can lead to congenital adrenal hyperplasia.
- Other names
- Cytochrome P450 11B1Steroid 11-beta-hydroxylaseP450c11β
02
Mechanism of action
Inhibition of steroid 11-beta-hydroxylation
03
Biological functions
SteroidogenesisCortisol synthesisGlucocorticoid productionHydroxylationEndocrine signaling
04
Disease associations
Congenital adrenal hyperplasiaCushing's syndromeHypertensionAdrenal insufficiency
05
Safety considerations
Adrenal insufficiencyHypotensionElectrolyte imbalancesDrug-drug interactions
06
Interacting drugs
Metyrapone
3 more in the full profile.
07
Biomarkers
11-DeoxycortisolCortisolACTH
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