p53-Independent Apoptosis Pathway

The p53-independent apoptosis pathway refers to mechanisms of programmed cell death that occur without the involvement of the tumor suppressor protein p53. Triggering events include DNA damage, ribosomal stress, telomere dysfunction, and cytokine signaling (e.g., TNF-α). Key molecular mediators include SLFN11, GCN2 kinase, ZAKα, and the JNK pathway. This pathway serves as a backup mechanism for eliminating damaged or abnormal cells, especially in cancers with TP53 mutations. Disruption of this pathway, such as through loss of SLFN11, can lead to chemoresistance. Targeting this pathway offers potential therapeutic strategies for TP53-mutant tumors.

Other names

p53-independent cell deathAlternative apoptosis pathwayNon-p53 mediated apoptosis

Various, depending on the specific pathway. Examples include: Activation of JNK pathway, Activation of death receptors (e.g. TNF-alpha receptor), Ribosome stalling and ZAKα-mediated activation of apoptosis