p53-induced noncoding RNA (PINCR)

p53-induced noncoding RNA (PINCR) is a long noncoding RNA (lncRNA) encoded by the human genome (gene alias RP3-326I13.1), identified as a direct transcriptional target of the tumor suppressor p53. PINCR is induced over 100-fold in response to DNA damage in a p53-dependent manner, particularly in colorectal cancer cells. It promotes prosurvival functions by recruiting the RNA-binding protein Matrin 3 to enhancer regions of specific p53 target genes involved in G1 cell cycle arrest and resistance to apoptosis—precisely, BTG2, RRM2B, and GPX1. PINCR thus helps regulate a selective subset of the p53 transcriptional network, acting as a context-dependent pro-survival factor during genotoxic stress. Targeted deletion of PINCR impairs G1 cell cycle arrest and increases sensitivity to chemotherapy-induced cell death, but its direct targeting by pharmacological agents remains unreported. PINCR’s function highlights the crucial regulatory roles played by lncRNAs in tumor cell fate decisions following DNA damage[1][2].

Other names

PINCRRP3-326I13.1

Not directly targeted by drugs; PINCR regulates gene expression by binding to Matrin 3, which associates with p53 and enhancer regions of specific p53 target genes[1][2].