P53 regulation associated long non-coding RNA (PRAL)

P53 regulation associated long non-coding RNA (PRAL), also referred to as lncRNA-PRAL, is a long non-coding RNA (lncRNA) molecule involved in post-transcriptional gene silencing and regulation of gene expression related to the p53 pathway[1]. PRAL is upregulated in response to stress signals that activate p53, such as DNA damage. It modulates the expression of a subset of p53 target genes, particularly those involved in cell cycle arrest and survival, rather than directly affecting p53 or p21 levels themselves. This lncRNA acts as a coactivator with specific RNA-binding proteins to facilitate expression of genes related to cell survival after DNA damage, and its dysregulation has been linked to various cancers. PRAL does not represent a traditional therapeutic target such as an enzyme or receptor, but rather functions as a regulatory RNA[1].

Other names

lncRNA-PRALP53 Regulation Associated LncRNA