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Target intelligence / Profile preview
p53 Up-Regulated Modulator of Apoptosis (PUMA)
- Target
- PUMA
- Molecular classification
- BCL–2 protein family, BH3-only protein
01
Overview
PUMA (p53 Up-Regulated Modulator of Apoptosis) is a pro-apoptotic protein belonging to the BH3-only subgroup of the BCL-2 protein family. It plays a critical role in mediating apoptosis in response to various cellular stresses by antagonizing anti-apoptotic BCL-2 family members, ultimately leading to mitochondrial outer membrane permeabilization and caspase activation. It is transcriptionally regulated by p53 and other factors, linking it to cancer development and therapy resistance.
- Other names
- BBC3Bcl-2-binding component 3
02
Mechanism of action
Binds to and antagonizes anti-apoptotic BCL-2 family members, promoting BAX/BAK activation and mitochondrial outer membrane permeabilization.
03
Biological functions
ApoptosisCell deathRegulation of mitochondrial outer membrane permeabilization
04
Disease associations
CancerNeurodegenerative diseaseCardiovascular diseaseTherapy resistance
05
Safety considerations
Excessive activation may lead to tissue damage due to excessive apoptosis
06
Interacting drugs
BH3 mimetics
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