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Target intelligence / Profile preview
p70 ribosomal protein S6 kinase (p70S6K)
- Target
- p70S6K
- Molecular classification
- Enzyme, Serine/threonine protein kinase, S6 kinase family
01
Overview
p70 ribosomal protein S6 kinase (p70S6K or S6K1) is a serine/threonine kinase that plays a key role in translation regulation, cell growth, and metabolism. It is activated by the PI3K/mTOR pathway and phosphorylates the ribosomal protein S6, enhancing translation of mRNAs encoding ribosomal proteins and elongation factors. Dysregulation of p70S6K is implicated in various diseases including cancer, diabetes, and fibrotic conditions, making it a therapeutic target.
- Other names
- S6K1RPS6KB1
02
Mechanism of action
Small-molecule inhibitors targeting p70S6K; Inhibition of mTORC1 to indirectly affect p70S6K activity.
03
Biological functions
Translation regulationCell growthCell proliferationMetabolic regulationRegulation of insulin sensitivityCell cycle progressionCell survival
04
Disease associations
CancerType 2 diabetesObesityFibrotic diseasesPulmonary fibrosis
05
Safety considerations
Narrow therapeutic index of mTOR inhibitorsPotential side effects of kinase inhibitors
06
Interacting drugs
mTOR inhibitors
1 more in the full profile.
07
Biomarkers
Plasma levels of p70S6K (for monitoring response to mTOR inhibitors)
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