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Paenibacillus larvae

Molecular classification: Bacterium

Overview

Paenibacillus larvae is a Gram-positive, spore-forming bacterium that causes American foulbrood (AFB) in honey bee larvae. Its spores are highly resistant, making eradication difficult. Key virulence factors include enzymes like PlCBP49, which degrades the peritrophic matrix. Genetic diversity is classified into ERIC genotypes. Treatment is challenging due to antibiotic resistance, prompting research into phage therapy.

Mechanism of action

Antibiotics target bacterial processes; bacteriophages infect and lyse bacteria.

Biological functions

PathogenInfection

Disease associations

American Foulbrood (AFB)

Safety considerations

Antibiotic resistanceSpore persistenceEradication challenges

Interacting drugs

Antibiotics

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