PALM2 and AKAP2 fusion protein (PALM2AKAP2)

The PALM2 and AKAP2 fusion protein (PALM2AKAP2) results from a readthrough transcriptional fusion between the paralemmin 2 (PALM2) and A-kinase anchor protein 2 (AKAP2) genes, which are located adjacently on chromosome 9q31.3. It encodes a protein capable of binding the regulatory subunit (RII) of protein kinase A (PKA), likely acting as a scaffold to localize PKA activity to specific subcellular sites. This fusion is also called "paralemmin A kinase anchor protein". The fusion is protein-coding and exists as one of three protein isoforms derived from the locus: PALM2, AKAP2, and PALM2-AKAP2. The specific biological significance and functional impacts of the PALM2-AKAP2 fusion isoform are not well understood. However, the protein may integrate PKA signaling with downstream effectors and modulate the actin cytoskeleton. The gene/fusion has been identified in fusion events in several cancers, with reports of its involvement in prostate cancer and pan-cancer fusions, but there are no known drug interactions or established mechanisms of pharmacological action. It is not considered a therapeutic target or receptor, nor is it a characterized clinical biomarker. **Additional context and caveats:** - PALM2AKAP2 is a fusion gene/protein, not a typical therapeutic target such as a receptor, enzyme, transporter, or channel. - There is no evidence it functions as a classic drug target or that any approved drugs directly interact with it. - Most functional insights are extrapolated from domain knowledge regarding AKAP2 family scaffolds and general PKA signaling pathways, not from direct assay of the fusion protein itself. - Existence and function of the fusion isoform are more relevant to gene annotation, structural genomics, and cancer fusion databases than drug targeting or clinical biomarker utility.

Other names

PALM2-AKAP2 fusion proteinPALM2AKAP2KIAA0920PAKAPPALM2AKAP-2PRKA2A-kinase anchor protein 2AKAP-KLParalemmin A kinase anchor proteinParalemmin-2Protein kinase A-anchoring protein 2AKAP2AKAPKLMISP2PALM2-AKAP2 readthroughProtein kinase A anchoring protein 2Protein kinase A2