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Target intelligence / Profile preview
Palmitoylethanolamide (PEA)
- Target
- PEA
- Molecular classification
- Endogenous fatty acid amide, Lipid modulator, N-acylethanolamine
01
Overview
Palmitoylethanolamide (PEA) is a naturally occurring lipid molecule that functions as an anti-inflammatory and analgesic agent. It primarily acts by activating PPAR-alpha, leading to the suppression of inflammatory gene expression and stabilizing mast cells. It is considered a safe and well-tolerated non-steroidal option, particularly for dermatological applications and potentially for systemic inflammation-related disorders.
- Other names
- Palmitamide MEAN-(2-hydroxyethyl)palmitamidePalmidrolHydroxyethylpalmitamide
02
Mechanism of action
Activation of PPAR-alpha leading to reduced transcription of pro-inflammatory genes; mast cell stabilization; modulation of TRPV1 channels; interaction with GPR55/GPR119 receptors.
03
Biological functions
Anti-inflammatory activityAnalgesic effectsBarrier repairModulation of immune responsesMast cell stabilization
04
Disease associations
Atopic dermatitisChronic painNeuropathic painFibromyalgiaNeuroinflammationNeurodegenerative disease
05
Safety considerations
None reported; generally well-tolerated.
06
Interacting drugs
Topical corticosteroids
1 more in the full profile.
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