Palmitoyltransferase ZDHHC14 (ZDHHC14)

Palmitoyltransferase ZDHHC14 is a member of the DHHC (Asp-His-His-Cys) motif-containing palmitoyl acyltransferases, enzymes responsible for S-palmitoylation of proteins, a post-translational modification involving the addition of palmitate to cysteine residues. ZDHHC14 is distinguished by its unique C-terminal Type-I PDZ ligand (LSSV) and is highly expressed in the hippocampus, where it plays a critical role in palmitoylating and appropriately localizing key neuronal proteins such as PSD93 and Kv1-family potassium channels. Its activity is essential for normal voltage-gated potassium channel clustering at the axon initial segment and thus for regulating neuronal excitability. Loss of ZDHHC14 disrupts this process, affecting electrical properties of neurons. ZDHHC14’s function appears to be non-redundant, and it is intolerant to loss-of-function mutations in humans[1][3][5][4]. There are currently no approved drugs or chemical probes known to selectively target ZDHHC14, and none of its interacting drugs or safety concerns have been identified in clinical settings.

Other names

DHHC-14NEW1CPFLJ20984DHHC domain-containing cysteine-rich protein 14NEW1 domain-containing proteinZinc finger DHHC domain-containing protein 14zinc finger DHHC-type containing 14zinc finger DHHC-type palmitoyltransferase 14zinc finger, DHHC domain containing 14

Not applicable (no approved drugs or tool compounds known to target ZDHHC14 directly)