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Target intelligence / Profile preview
Pancreatic Adenocarcinoma Upregulated Factor
- Molecular classification
- Secreted protein, Glycoprotein
01
Overview
Pancreatic adenocarcinoma upregulated factor (PAUF) is a secreted, N-glycosylated protein highly overexpressed in pancreatic cancer and some other cancers like cervical adenocarcinoma. It promotes tumor growth, migration, invasion, angiogenesis, and immune evasion by modulating the tumor microenvironment, including increasing the number and suppressive function of myeloid-derived suppressor cells (MDSCs). PAUF is considered a potential diagnostic biomarker and therapeutic target, with a monoclonal antibody (PBP1510) under development. High PAUF expression correlates with poorer survival outcomes.
02
Mechanism of action
PBP1510: Binds specifically to PAUF, neutralizing its activity.
03
Biological functions
Cell proliferationCell migrationAngiogenesisImmune evasionMetastasis
04
Disease associations
Cancer
05
Interacting drugs
Gemcitabine
2 more in the full profile.
06
Biomarkers
PAUF expression levels in tumor tissuePAUF levels in serum/plasma
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