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Target intelligence / Profile preview
Pancreatic alpha-amylase (PA)
- Target
- PA
- Molecular classification
- Enzyme, Glycoside Hydrolase
01
Overview
Pancreatic alpha-amylase is a digestive enzyme secreted by the pancreas into the small intestine, where it plays a central role in carbohydrate digestion. It catalyzes the hydrolysis of internal α(1→4) glycosidic bonds in starches to yield maltose and other oligosaccharides. Serum levels serve as diagnostic markers for acute pancreatitis and other exocrine pancreatic disorders.
- Other names
- AMY2AAMY2B1,4-alpha-D-glucan glucanohydrolase
02
Mechanism of action
Inhibition of alpha-amylase, slowing carbohydrate absorption
03
Biological functions
DigestionCarbohydrate MetabolismHydrolysis of alpha(1->4) glycosidic bonds
04
Disease associations
PancreatitisExocrine pancreatic disorders
05
Safety considerations
Elevated levels may indicate pancreatic disorders, but are not specific.Inhibition can lead to gastrointestinal side effects.
06
Interacting drugs
Acarbose
07
Biomarkers
Serum levels of pancreatic alpha-amylase (for pancreatitis diagnosis)
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