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Target intelligence / Profile preview
Pancreatic Endocrine Cell (N/A)
- Target
- N/A
- Molecular classification
- Cell type, Endocrine cell, Hormone-secreting cell
01
Overview
Pancreatic endocrine cells are specialized hormone-producing cells located within the islets of Langerhans in the pancreas. They are responsible for regulating blood glucose and overall metabolic homeostasis by secreting key hormones directly into the bloodstream. The main types of endocrine cells include alpha cells (glucagon), beta cells (insulin), delta cells (somatostatin), PP cells (pancreatic polypeptide), and epsilon cells (ghrelin).
- Other names
- Islet cellsCells of the Islets of LangerhansAlpha cellsBeta cellsDelta cellsPP cellsEpsilon cellsGlucagon-producing cellsInsulin-producing cellsSomatostatin-producing cellsPancreatic polypeptide-producing cellsGhrelin-producing cells
02
Mechanism of action
N/A - These are cells, not drug targets. Drugs listed interact with the hormones they secrete or other related pathways.
03
Biological functions
Hormone secretionBlood glucose regulationMetabolic homeostasisInsulin secretionGlucagon secretionSomatostatin secretionPancreatic polypeptide secretionGhrelin secretionRegulation of exocrine pancreatic secretionsGastrointestinal motility regulationAppetite modulation
04
Disease associations
Diabetes mellitusHyperglycemiaHypoglycemiaMetabolic disordersPancreatic cancer (indirectly through tumor microenvironment)
05
Safety considerations
Hypoglycemia (insulin excess)Hyperglycemia (insulin deficiency)Adverse effects of drugs targeting hormone secretionAutoimmune destruction of beta cells (Type 1 Diabetes)
06
Interacting drugs
Insulin
5 more in the full profile.
07
Biomarkers
Insulin levelsGlucagon levelsSomatostatin levelsPancreatic polypeptide levelsGhrelin levelsHbA1c (glycated hemoglobin)C-peptide (insulin secretion marker)Glucose tolerance test (GTT)
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