Pancreatic lipase-related protein 1 (PNLIPRP1)

Pancreatic lipase-related protein 1 (PNLIPRP1) is a member of the pancreatic lipase gene family, predominantly expressed in the pancreas and secreted into the digestive tract.[3][2] PNLIPRP1 shares significant sequence homology with other pancreatic lipases but is catalytically inactive and lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids, or cholesterol esters.[5][3] Structural and functional studies suggest it may act as an endogenous inhibitor or regulator of dietary triglyceride digestion by inhibiting the activity of pancreatic triglyceride lipase (PNLIP) and colipase-mediated lipid hydrolysis.[7][5] PNLIPRP1 is predicted to bind calcium ions and is localized predominantly in the extracellular region.[4] There is no strong evidence for a direct disease role or for pharmacological targeting, but it has been cited as a potential biomarker for prostate cancer.[4] Key points: - Catalytically inactive within the lipase family; does not hydrolyze typical lipase substrates.[5][3] - May function as an inhibitor in dietary lipid digestion, with possible metabolic regulatory roles.[6][7][5] - No known interacting drugs or small molecules; not an established therapeutic target.[3][5] - Aliases include PLRP1, PL-RP1, and LIPR1.[3][5] - Potential, but unconfirmed, role as a biomarker in prostate cancer.[4][3] - No significant therapeutic or safety data reported.

Other names

Inactive pancreatic lipase-related protein 1PLRP1PL-RP1LIPR1

Not applicable (no known drugs target this protein)