Pancreatic lipase-related protein 2 (PNLIPRP2)

Pancreatic lipase-related protein 2 (PNLIPRP2) is an enzyme primarily secreted by the pancreas that plays a critical role in the digestion and absorption of dietary fats by hydrolyzing triglycerides into monoglycerides and fatty acids[1][2][3][4][6]. It belongs to the pancreatic lipase family and is structurally characterized by an α/β hydrolase fold and a substrate-binding lid domain that influences substrate specificity and interfacial activation[1][2][5]. PNLIPRP2 is closely related to, but functionally distinct from, canonical pancreatic lipase (PNLIP); it can function independently of colipase and may have unique roles in the digestion of certain lipids[1][2]. Drugs that inhibit lipase activity, such as orlistat, are used to treat obesity by limiting fat absorption[6]. "Lipase 2" is not the preferred scientific name, and structured data should be based on the full designation above; further clarification is recommended to avoid ambiguity.

Other names

pancreatic lipase-related protein 2PNLIPRP2PLRP2

Competitive inhibition of the catalytic site (e.g., orlistat blocks substrate access, preventing triglyceride hydrolysis)