Pancreatic lipase-related protein 2 pseudogene

Pancreatic lipase-related protein 2 pseudogene (ENSG00000189372) is a non-functional genomic locus related to the PNLIPRP2 gene, which encodes a lipase involved in the hydrolysis of dietary galactolipids and triglycerides. The pseudogene lacks protein-coding capacity, distinguishing it from its functional paralog, PNLIPRP2 (Pancreatic lipase-related protein 2)[5]. PNLIPRP2 itself is expressed primarily in the pancreas, participates in dietary fat digestion, and is implicated in intestinal fat absorption, especially in neonates and in some pathological states[1][3][5]. However, the pseudogene form does not produce a functional enzyme and has no direct biological or therapeutic significance. Key distinction: - The **functional target** is "Pancreatic lipase-related protein 2" (PNLIPRP2), which is a secreted **lipase enzyme** with established metabolic and disease associations[1][3][5]. - **ENSG00000189372** as labeled is a **pseudogene** and **not a valid drug target**[5].

Other names

PNLIPRP2 pseudogeneLIPR2 pseudogenePNLIPRP2P