Pancreatic Tissue Regeneration

Pancreatic tissue regeneration refers to the process by which the pancreas repairs or replaces its damaged or lost cells, restoring both exocrine (acinar and ductal) and endocrine (islet, especially β-cell) functions. This regenerative capacity is of particular interest for treating diseases such as diabetes mellitus and pancreatitis. Key mechanisms include β-cell replication, neogenesis from progenitor cells, and transdifferentiation of other pancreatic cell types. Several transcription factors like PDX1, NGN3, SOX9, HNF1β, and MAFA are central to the process. Experimental models such as partial pancreatectomy, pancreatic duct ligation, and chemically induced pancreatitis are used to study regeneration. Understanding these mechanisms provides a foundation for developing therapies aimed at restoring endogenous insulin production in diabetes and repairing exocrine function following pancreatitis.

Stimulation of β-cell replication, neogenesis from progenitor cells, or transdifferentiation of other pancreatic cell types into β-cells.