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Target intelligence / Profile preview
Pancreatic Tumor Associated Antigens (Pancreatic TAAs)
- Target
- Pancreatic TAAs
- Molecular classification
- Protein, Glycoprotein, Carbohydrate, Receptor, Ligand, Enzyme, Tight junction protein, Inhibitor protein
01
Overview
Pancreatic tumor associated antigens (TAAs) are molecules overexpressed or aberrantly expressed on pancreatic cancer cells compared to normal tissues. They serve as biomarkers for diagnosis, prognosis, and targets for immunotherapy. Key TAAs include ADAM9, EFNB2, MET, TMOD3, TPX2, WNT7A, Claudin18.2, MUC1, CEA, Survivin, Telomerase, and carbohydrate-related antigens like CA19-9 and CA125. They are targets for vaccines and antibody therapies.
- Other names
- Pancreatic cancer antigensPDAC tumor antigens
02
Mechanism of action
Varies depending on the specific TAA and therapeutic approach. Examples include: Induction of cytotoxic T lymphocyte (CTL) responses, antibody-mediated cell cytotoxicity (ADCC), inhibition of receptor signaling, disruption of cell-cell interactions.
03
Biological functions
Immune responseCell proliferationCell deathSignal transductionApoptosis InhibitionCell adhesionCell-cell interactions
04
Disease associations
CancerPancreatic CancerPancreatic Ductal Adenocarcinoma (PDAC)
05
Safety considerations
On-target, off-tumor toxicityImmune-related adverse events (irAEs)Tumor microenvironment immunosuppression limiting efficacyAntigen escape/loss of expressionHeterogeneous antigen expression across patients and within tumors
06
Interacting drugs
Monoclonal antibodies (e.g., targeting Claudin18.2)
3 more in the full profile.
07
Biomarkers
CA19-9CA125Claudin18.2 expression levelMUC1 expressionCEA expressionSurvivin expressionhTERT/GV1001 expression
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