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Target intelligence / Profile preview
Pannexin 1 Channel (Panx1)
- Target
- Panx1
- Molecular classification
- Ion channel, Membrane channel protein
01
Overview
Pannexin 1 (Panx1) is a widely expressed membrane channel protein that forms large-pore, non-selective channels permeable to ions and small molecules, most notably ATP. Panx1 channels play critical roles in physiological and pathophysiological processes across the nervous, cardiovascular, and immune systems. It mediates ATP release for purinergic signaling and contributes to inflammation, cell death, blood pressure regulation, and calcium wave propagation. Panx1 is a potential therapeutic target in diseases such as asthma, hypertension, stroke, and seizures.
02
Mechanism of action
Channel blockade, inhibition of ATP release
03
Biological functions
Purinergic signalingIntercellular communicationInflammationCell deathBlood pressure regulationCalcium wave propagation
04
Disease associations
AsthmaHypertensionAtherosclerosisIschemic injuryStrokeSeizures
05
Safety considerations
Specificity of inhibitors variesOff-target effects of connexin hemichannel blockers
06
Interacting drugs
^10Panx^11 peptide
4 more in the full profile.
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