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Target intelligence / Profile preview
Pannexin 1 Channel Protein (Panx1)
- Target
- Panx1
- Molecular classification
- Ion channel, Large-pore channel
01
Overview
Pannexin 1 (Panx1) is a large-pore, non-selective channel protein widely expressed in mammalian tissues. It is best known for its role in mediating the release of ATP and other nucleotides, thereby participating in purinergic signaling. Panx1 channels are activated by diverse stimuli such as mechanical stress, voltage changes, increased intracellular calcium levels, and receptor signaling. Dysregulation of Panx1 has been implicated in several diseases, including asthma, hypertension, and cancer, making it an attractive therapeutic target for modulating inflammatory responses or pathological purinergic signaling.
02
Mechanism of action
Modulating channel opening and ion/metabolite flux
03
Biological functions
ATP releasePurinergic signalingBlood pressure regulationImmune response modulationApoptotic cell clearanceCell death pathways
04
Disease associations
AsthmaAtherosclerosisHypertensionIschemia-induced seizuresNeuropathic painCancer
05
Safety considerations
Potential for off-target effects due to wide tissue distributionFunctional plasticity and complex regulation make targeted drug development challenging
06
Interacting drugs
Carbenoxolone
07
Biomarkers
PANX1 overexpression (in some cancers)
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