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Target intelligence / Profile preview
Panton-Valentine Leukocidin (PVL)
- Target
- PVL
- Molecular classification
- Exotoxin, Pore-forming toxin, Bicomponent toxin
01
Overview
Panton-Valentine leukocidin (PVL), also known as LukSF, is a bicomponent, pore-forming cytotoxin produced by certain strains of *Staphylococcus aureus*. It is composed of two protein subunits: LukS-PV and LukF-PV. It functions by forming pores in immune cell membranes, leading primarily to neutrophil lysis—a process central to its pathogenicity. PVL is strongly associated with increased virulence in community-associated methicillin-resistant *S. aureus* (CA-MRSA) and some methicillin-susceptible strains. The primary receptor for PVL on human cells is the C5a receptor (hC5aR).
- Other names
- LukSF
02
Mechanism of action
Pore formation in immune cell membranes
03
Biological functions
Cell lysisImmune suppressionNeutrophil activationApoptosis induction
04
Disease associations
InfectionSkin and soft tissue infectionsNecrotizing pneumoniaStaphylococcus aureus infections
05
Safety considerations
Severe tissue necrosisHigh mortality rate in necrotizing pneumoniaNeutrophil lysis can compromise host defense
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