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Target intelligence / Profile preview
Panton-Valentine Leukocidin S subunit (LukS-PV)
- Target
- LukS-PV
- Molecular classification
- Toxin, Pore-forming toxin subunit
01
Overview
LukS-PV is the S subunit of Panton-Valentine leukocidin (PVL), a bicomponent pore-forming cytotoxin secreted by Staphylococcus aureus. It binds to receptors on human neutrophils, primarily C5aR1, initiating the formation of transmembrane pores with LukF-PV, leading to cell lysis or apoptosis. Beyond its role in pore formation, isolated LukS-PV can induce apoptosis in leukemia cells via multiple signaling pathways, showing potential as an antileukemia agent. It's associated with increased virulence in CA-MRSA infections.
- Other names
- PVL S componentLukS-PV
02
Mechanism of action
Binds to host cell receptors (C5aR1, C5L2), initiates assembly with LukF-PV subunit, forms pores in cell membrane leading to lysis or apoptosis. Alone can induce apoptosis via multiple signaling pathways independent from pore formation.
03
Biological functions
Pore formationCell lysisApoptosis inductionImmune evasionReceptor binding
04
Disease associations
InfectionStaphylococcus aureus infectionCommunity-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infectionSkin and soft tissue infectionsNecrotizing pneumoniaLeukemia
05
Safety considerations
Potential for off-target effects related to immune cell lysis.Concentration-dependent cytotoxicity.
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