Target intelligence / Profile preview

Pantothenate Kinase (PanK)

Target: PanK
Molecular classification: Enzyme, Kinase

Overview

Pantothenate kinase (PanK), also known as CoaA, is the first and rate-limiting enzyme in the coenzyme A (CoA) biosynthetic pathway. It catalyzes the phosphorylation of pantothenate to 4'-phosphopantothenate, using ATP. Mutations in PANK2 cause pantothenate kinase-associated neurodegeneration (PKAN).

Other names: CoaA

Mechanism of action

Phosphorylation of pantothenate (vitamin B5) using ATP as a phosphate donor.

Biological functions

Coenzyme A biosynthesisPhosphorylation of pantothenic acidMetabolic regulation

Disease associations

Pantothenate kinase-associated neurodegeneration (PKAN)

Safety considerations

Targeting CoA biosynthesis could have broad metabolic effects.

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