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Pantothenic Acid Biosynthesis
- Molecular classification
- Enzyme
01
Overview
Pantothenic acid biosynthesis refers to the metabolic pathway by which organisms synthesize pantothenic acid (vitamin B5), a vital precursor for the production of coenzyme A (CoA). CoA is an essential cofactor involved in numerous biochemical reactions, including fatty acid metabolism, synthesis and degradation of phospholipids, operation of the tricarboxylic acid cycle, and more. It is a target for antimicrobial drug development because humans lack this pathway but many pathogens require it for survival.
- Other names
- Vitamin B5 biosynthesisPantothenate biosynthesisCoenzyme A biosynthesis (early steps)
02
Mechanism of action
Inhibition of bacterial pantothenate biosynthesis enzymes
03
Biological functions
Vitamin biosynthesisCoenzyme A biosynthesisMetabolism
04
Disease associations
Infection
05
Safety considerations
Potential for off-target effects if targeting broadly conserved enzymesDevelopment of resistance in pathogens
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