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Target intelligence / Profile preview
Papillary thyroid carcinoma susceptibility candidate 1 (non-protein coding) (PTCSC1)
- Target
- PTCSC1
- Molecular classification
- long non-coding RNA, lncRNA
01
Overview
Papillary thyroid carcinoma susceptibility candidate 1 (PTCSC1) is a long non-coding RNA (lncRNA) located at chromosome 8q24, identified through genetic linkage and association studies as a susceptibility locus for papillary thyroid carcinoma (PTC)[1][3][4]. PTCSC1 itself does not encode a protein but may function as a tumor suppressor RNA and is implicated in the regulation of gene expression related to thyroid carcinogenesis[3][1]. Variants at the PTCSC1 locus are associated with increased risk of PTC and possibly with susceptibility to other cancers[3]. PTCSC1 is not considered a canonical therapeutic target such as a receptor, enzyme, or transporter, and there are currently no known drugs that directly interact with it. It serves as a putative biomarker for genetic risk in PTC[3][1].
- Other names
- AK023948NCRNA00197non-protein coding RNA 197PTCSCpapillary thyroid carcinoma susceptibility candidate (non-protein coding)papillary thyroid carcinoma susceptibility candidate 1 (non-protein coding)
02
Biological functions
putative tumor suppressorregulation of gene expression
03
Disease associations
Papillary thyroid carcinomaPredisposition to other cancers via the 8q24 locus
04
Biomarkers
Potential genetic biomarker for papillary thyroid carcinoma susceptibility
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