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Paracrine Immunomodulation via Mesenchymal Stem Cells (MSC Paracrine Immunomodulation)
- Target
- MSC Paracrine Immunomodulation
- Molecular classification
- Cellular mechanism/process, Cytokines, Chemokines, Growth Factors, Extracellular vesicles
01
Overview
Paracrine immunomodulation via mesenchymal stem cells (MSCs) refers to the process by which MSCs influence immune responses primarily through the secretion of soluble factors and extracellular vesicles, rather than direct cell-to-cell contact. This paracrine activity is a key mechanism underlying the therapeutic potential of MSCs in modulating both innate and adaptive immunity.
- Other names
- MSC-mediated paracrine immunomodulationMesenchymal stem cell paracrine signaling in immunomodulation
02
Mechanism of action
Modulates local/systemic immunity through secreted bioactive molecules without requiring direct cellular contact.
03
Biological functions
ImmunosuppressionImmunomodulationPromotion of anti-inflammatory phenotypesPromotion of regulatory phenotypesInhibition of proinflammatory cytokine productionTissue repairRegeneration
04
Disease associations
Autoimmune diseasesInflammatory disordersTissue injuryGraft-versus-host diseaseLung injuryCOVID-related ARDS
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