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Paracrine-mediated angiogenesis
- Molecular classification
- Pathway, Signaling pathway
01
Overview
Paracrine-mediated angiogenesis refers to the process by which new blood vessels form from pre-existing vasculature, driven by the secretion of soluble factors (paracrine signals) from one cell type that act on neighboring cells—most notably endothelial cells—to stimulate angiogenic responses. Key mediators include VEGF, HGF, bFGF, Angiopoietins, and Interleukins. This mechanism is central in tissue repair, regeneration, and pathological conditions such as tumor growth. Therapies may use either whole-cell approaches leveraging their secretome/paracrinally active products or purified/recombinant forms/EV-based delivery systems mimicking this natural process.
02
Mechanism of action
Inhibition or promotion of angiogenesis via modulation of paracrine signaling
03
Biological functions
AngiogenesisVasculogenesisTissue repairCell proliferationCell migration
04
Disease associations
CancerIschemic diseasesTissue regenerationWound healing
05
Safety considerations
Uncontrolled angiogenesis (e.g., tumor growth)Vascular leakinessOff-target effects of angiogenic factors
06
Interacting drugs
Anti-VEGF antibodies
1 more in the full profile.
07
Biomarkers
VEGF levelsHGF levelsAngiogenic factors in tissue or serum
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