Paracrine signaling via secretion of trophic factors and extracellular vesicles

Paracrine signaling via secretion of trophic factors and extracellular vesicles is a fundamental biological process by which cells communicate with their neighbors. Cells release a variety of signaling molecules—including proteins, growth factors, and lipids—or package bioactive cargo into extracellular vesicles (such as exosomes and microvesicles), which then transfer to target cells and modify cellular behavior. This mechanism is crucial in regulating tissue development, repair, immune function, and disease states like cancer. However, "paracrine signaling via secretion of trophic factors/extracellular vesicles" is not a specific molecular target, but a collective term capturing several pathways and mechanisms that can vary widely in molecular detail according to context

Other names

Paracrine signalingExtracellular vesicle-mediated communicationParacrine effectorsEV signalingSecreted trophic factor signaling

Modulation of receptor-ligand interactions by blocking, mimicking, or enhancing extracellular vesicle signaling Inhibition or stimulation of vesicle biogenesis, release, or uptake Interference with secretion or reception of trophic factors