Paracrine signaling via secretome

"Paracrine signaling via secretome" does not refer to a specific molecule or receptor but rather describes a **mode of cell-to-cell communication** in which cells secrete various factors—collectively known as the **secretome**—that act on nearby cells to alter their behavior, survival, proliferation, or differentiation. The secretome includes proteins such as growth factors, cytokines, chemokines, extracellular vesicles/exosomes, and other bioactive molecules. These signals typically act over short distances within tissues and are essential for processes like tissue homeostasis, wound healing, angiogenesis (formation of new blood vessels), immune modulation, and development. In regenerative medicine research—including stem cell therapy—the therapeutic effects are often attributed more to the paracrine action of the secreted factors than direct engraftment or replacement by transplanted cells. Because "paracrine signaling via secretome" is not itself a single gene product or druggable entity but rather an umbrella term for many different molecules acting through diverse pathways in local tissue environments—and because it lacks specificity—it should not be considered a canonical therapeutic target. If you need structured information about individual components involved in paracrine signaling (such as fibroblast growth factor receptor [FGFR], vascular endothelial growth factor [VEGF] receptors), those should be specified individually.

Other names

Paracrine signalingParacrine secretionParacrine communicationSecretome-mediated paracrine signaling