Paracrine signaling via transfer of bioactive molecules (null)

Paracrine signaling is a form of intercellular communication in which cells release bioactive molecules—such as growth factors, peptides, cytokines, and morphogens—that diffuse over short distances to influence nearby cells, eliciting changes in their behavior and function[1][2][3][4]. Key features of paracrine signaling include local action, specificity via cell-surface receptors, and rapid degradation or uptake of signaling molecules to limit their range and duration[1][2][3][4][7]. It plays a central role in development, tissue homeostasis, regeneration, immune responses, vascular tone, and wound repair[1][4][6][7][8]. Many distinct molecular pathways contribute to paracrine signaling, including the FGF, Wnt, Notch, and Hedgehog pathways, as well as nitric oxide and cytokines[1][2][3][4][6][7][8]. Disruption of paracrine signaling is implicated in diverse diseases, including cancer, fibrosis, cardiovascular disease, and inflammatory disorders[4][8]. Because "paracrine signaling via transfer of bioactive molecules" refers to a process—not a defined molecular entity, receptor, or drug target—the entry is considered incorrect for structured target information, and specific molecular details should be sought for individual mediators (e.g., "Vascular endothelial growth factor receptor," "Epidermal growth factor receptor," "Interleukin-6 receptor") within the paracrine signaling paradigm[1][3][4][8].

Other names

Paracrine communicationParacrine factor signalingLocal cell signaling

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