Target intelligence / Profile preview

Parainfluenza Virus Type 3 Glycoprotein (HPIV3 Glycoprotein)

Target: HPIV3 Glycoprotein
Molecular classification: Viral protein, Glycoprotein, Hemagglutinin, Neuraminidase, Fusion protein

Overview

Human parainfluenza virus type 3 (HPIV3) glycoproteins, specifically hemagglutinin-neuraminidase (HN) and fusion protein (F), are essential for viral entry and infection. HN binds to sialic acid receptors and activates F, which mediates membrane fusion. Both glycoproteins are major antigenic determinants and targets for neutralizing antibodies. Proteolytic activation of F by host serine proteases is crucial for its function. Sequence variation in these glycoproteins can lead to immune escape, posing challenges for vaccine development.

Other names: HPIV3 HNHPIV3 FHemagglutinin-Neuraminidase (HPIV3)Fusion protein (HPIV3)

Mechanism of action

HN binds to sialic acid receptors triggering F activation, which mediates membrane fusion.

Biological functions

Receptor bindingMembrane fusionViral entryViral releaseSialic acid cleavage

Disease associations

InfectionRespiratory illnessCroupBronchiolitisPneumonia

Safety considerations

Sequence variation in neutralization epitopes leading to immune escapeChallenges in developing broadly protective vaccines due to antigenic drift

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