Target intelligence / Profile preview

Paraoxonase 1 (PON1)

Target: PON1
Molecular classification: Enzyme, Ester hydrolase, Lactonase, Arylesterase, Paraoxonase

Overview

Paraoxonase 1 (PON1) is a calcium-dependent hydrolytic enzyme primarily associated with high-density lipoprotein (HDL). It exhibits esterase and paraoxonase activities, including the ability to hydrolyze organophosphate compounds. PON1 plays significant roles in cardiovascular health, detoxification of organophosphates, and protection against oxidative stress.

Mechanism of action

Hydrolyzes organophosphates and other substrates, preventing oxidative stress and inflammation.

Biological functions

Antioxidant defenseDetoxificationAnti-inflammatory

Disease associations

Cardiovascular diseaseAtherosclerosisDiabetes mellitus

Safety considerations

Variability in activity due to genetic polymorphismsPotential for drug interactions affecting PON1 activity

Interacting drugs

Organophosphates (e.g., Paraoxon, Parathion - substrates)

1 more in the full profile.

Biomarkers

PON1 activityPON1 serum concentrationPON1 genetic variants

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