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Paraoxonase 2 (PON2)
- Target
- PON2
- Molecular classification
- Enzyme, Arylesterase, Lactonase
01
Overview
Paraoxonase 2 (PON2) is an intracellular enzyme and a member of the paraoxonase gene family. It is ubiquitously expressed and acts as a cellular antioxidant, protecting cells from oxidative stress. It also hydrolyzes acyl-homoserine lactones, disrupting bacterial quorum sensing. PON2 is implicated in cardiovascular protection, neuroprotection, and cancer.
02
Mechanism of action
Inhibition of bacterial quorum sensing via acyl-homoserine lactone hydrolysis; Reduction of reactive oxygen species (ROS) levels.
03
Biological functions
Antioxidant protectionAnti-inflammatory responseBacterial quorum quenchingHydrolysis of acyl-homoserine lactones
04
Disease associations
Cardiovascular diseaseAtherosclerosisAlzheimer's diseaseNeurodegenerative diseaseCancerInfection
05
Safety considerations
Potential impact of altered expression/activity on disease outcomesImpact of polymorphisms on drug response
06
Biomarkers
Expression levels in tumorsAla147Gly polymorphismSer311Cys polymorphism
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