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Parasite Mitochondrial Electron Transport Chain (ETC)
- Target
- ETC
- Molecular classification
- Enzyme complex, Redox enzyme, Electron carrier, Oxidoreductase
01
Overview
The mitochondrial electron transport chain (ETC) in parasites is a series of protein complexes and associated molecules in the inner mitochondrial membrane. It's essential for parasite survival, primarily supporting pyrimidine biosynthesis during blood-stage infections. Unlike human mitochondria, it lacks Complex I and utilizes NDH2. Components like cytochrome b are targeted by antimalarial drugs, and resistance can arise through mutations.
- Other names
- Parasite ETCMitochondrial electron transport chain (parasite)Electron transport chain (parasite)Respiratory chain (parasite)
02
Mechanism of action
Inhibition of electron flow, disruption of ubiquinone binding, inhibition of dihydroorotate dehydrogenase activity, disruption of membrane potential
03
Biological functions
Electron transportRedox reactionsPyrimidine biosynthesis supportMembrane potential maintenanceUbiquinone reductionDihydroorotate dehydrogenase (DHOD) activity support
04
Disease associations
InfectionMalariaLeishmaniasisTrypanosomiasis
05
Safety considerations
Drug resistance (mutations at drug-binding sites)Off-target effects on host mitochondria
06
Interacting drugs
Atovaquone
3 more in the full profile.
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